Best March Madness Parlay Today: NCAA Parlay Bets

Leg 2: #1 Houston (-5) vs. #1 Duke

The Blue Devils are two games away from winning their first National Championship in the post-Coach K era. Duke has been dominant in the NCAA Tournament thus far, but all their remaining opponents are also number-one seeds. Their next test will be against the Houston Cougars.

First to 5 swishes (stay for the Larry Bird celly)👌😅 pic.twitter.com/WyNAhgPAAy

— Duke Men’s Basketball (@DukeMBB) April 1, 2025

March Madness betting sites have Duke laying 5 points against Houston in the Final Four. Duke has a top-10 offense that averages 83.7 PPG. However, the Cougars have the top scoring defense in Men’s college basketball, allowing only 58.3 PPG.

As good as the Houston defense has been, they face the unenviable task of trying to stop Cooper Flagg, the 2025 MOP frontrunner. Duke’s star freshman can cap off the best one-and-done season in recent memory with a title this year.

Flagg has plenty of help around him, too, including fellow freshman Kon Knueppel. The Blue Devils’ offense has scored at least 85 points in every game of the tournament. Houston will do their best to slow them down, but stopping such a talented offense is close to impossible, so I’m taking the favorite.